Exchange 2000 server problem

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We have just moved a client to SMTP mail from POP3 on SBS2000. Email seems
to get in to them some of the time, other times an error is returned to the
sender as seen below

Your message did not reach some or all of the intended recipients.
Subject: test from gary at 9:15 am Monday, please ignore
Sent: 26/09/2005 09:15
The following recipient(s) could not be reached:

usera@xxxxxxxxxxxxx on 26/09/2005 09:15

There was a SMTP communication problem with the recipient's email server.
Please contact your system administrator.

<domainb.co.uk #5.5.0 smtp;553 sorry, that domain isn't in my list of
allowed rcpthosts (#5.7.1)>

Anybody come across this before ? The mail is handled directly via the
exchange server, outgoing mail is delivered using DNS.

Thanks in advance

Gary




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