Unable to bind to the destination server in DNS

Not sure were to post this one, but I'll start in the DNS discussion.

My gateway mail server (Win2k3 IIS6 SMTP) will stop delivering e-mails. The
SMTP mail queue grows larger and acceptes inbound e-mails, but does not
deliver internetbound e-mails. The Following Event (4000) is added to the
Sytem event log.
It makes sence - can find the mail server for the domain, cant deliver to
it. However these events are spuradic and looking at my DNS cache, I se ethe
domains listed. Any ideas?

Event Type: Warning
Event Source: smtpsvc
Event Category: None
Event ID: 4000
Description:
Message delivery to the remote domain 'hotmail.com' failed for the following
reason: Unable to bind to the destination server in DNS.

.

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