auto response that emails have been recieved

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From: please help me (you)
Date: 03/18/04 

Date: Thu, 18 Mar 2004 12:38:02 -0000

need to find a program that actually works!!

what I would like is a programme that will inform me that someone HAS
actually got the email on there system or has read it even.

hope someone out there can help me.

thanks very much for any help given.

regards

Jason