Transfer some files from C:\Program Files

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I'd like to prune my C:\Program Files to hold only files I need daily.

There's a lot of stuff I've put in there which I rarely use, or have
stored an unused program because it may just come in useful sometime,
and I'd like to store them on my G: External Hard Drive.

Is it possible to transfer them and have them open when I click on
them or even to transfer one back to C: Drive temporarily to do a
specific task then return it later.
.