Security Warning

I have several computers running Windows XP w/ sp2 and I get a security
warning when I start to open a certain application. The message is listed
below.

The publisher could not be verified. Are you sure you want to run this
software?
Name:
Publisher:
Type:
From:
This file does not have a valid digital signature that verifies its
publisher. You should only run software from publishers you trust.

This software is being run from another organization that I know that has
the same configuration of windows XP sp2 with no problem. I am able to get
past this error by clicking the run button, but the only problem is that is a
nuissance and I have to click it several times.

My question is; is there a way that I can stop this message from displaying
every time that i start the software by editing something in the registry?

TIA
.