Safe to remove spyware?

From: NIGHTSHADE-UK™ (NIGHTSHADEUK_at_discussions.microsoft.com)
Date: 03/01/05 

Date: Tue, 1 Mar 2005 10:29:09 -0800

I have been religious in using SPybot and Ad-Aware SE Personal for a long
time now and have been happy with the results, however after trawling few
numerous posts on this site the last few days i decided to run a new check
with http://www.pandasoftware.com/activescan/com/ apprentley i have 19
infected files, most of which are tucked up in Adware somewhere, the others
are scattered in my registry, is it safe for me to remove them? Especially
this one exclean.exe.
I have the log which i can post if any wishes to see it.
Many Thanx Nightshade