Basic filter for Query newbie

I want to generate a report but filter out some records, depending on the
value of a certain field. From what I can gather reading the posts in the
Reports section, I need to do it from a Query but have no idea how.

This field simply has 1 character in it... and A, B or C etc.

For instance, I want my report to show all records except those that are set
to B, D or F etc

Any help would really be appreciated.
.

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